Escrito por Dr. Hannah K Shorrock Editado por Dr. Celeste Suart Traduzido para o Português por Priscila Pereira Sena A acumulação de danos ao DNA sem a capacidade de reparo pode levar a uma cascata de efeitos negativos na SCA7, resultando na morte neuronal. Por que os neurônios do cerebelo Read More…
Have you ever thought about why doctors tell us to eat protein-rich food? Why eating proteins is so important for our health and wellbeing? Well, it is because of what they consist of and how important proteins are to maintain our body functions under control. Amino acids are organic chemicals Read More…
Escrito por Dr. Gülin ÖzEditado por Dr. Celeste SuartTraduzido por Ana Carolina Martins A ressonância magnética (RM) detecta alterações cerebrais antes dos sintomas de ataxia. A lista de empresas farmacêuticas que direcionaram a sua atenção para as ataxias tem aumentado ao longo da última década. Isto se deve ao promissor Read More…
Written by Tala Ortiz Edited by Dr. Larissa Nitschke Repeat-associated non-AUG (RAN) translation in CAG repeat expansion diseases is toxic to cells and causes them to die. The Jain group found that RAN proteins and expanded RNA can be found in the same location in cells and interfere with essential Read More…
If you’ve ever felt shaky when speaking in public or after drinking too much coffee, then you’ve likely experienced tremor. Tremor is an involuntary, rhythmic shaking of parts of the body, such as the hands or the head. Everyone experiences a normal, physiological tremor at a certain level, which is Read More…
Written by Asmer Aliyeva Edited by Dr. Hannah K Shorrock Antisense Oligonucleotide (ASO) treatment improves Purkinje neuron function regulated by potassium channels and highlights altered brain connectivity in movement disruption in SCA3. Understanding which cell types are important for disease onset is vital for therapy development and treatment options for Read More…
Dystonia is a disorder that affects the way a person moves. Specifically, people with dystonia have involuntary muscle contractions, which can cause abnormal twisting postures. Dystonia can affect muscles anywhere in the body, including the face, neck, torso, and limbs. The impact of dystonia can vary greatly across individuals. Some Read More…
Incomplete penetrance is a characteristic of a wide range of genetic diseases, including hereditary forms of neurodegenerative disease, heart disease, and cancer. In short, it means that individuals carrying a disease-causing mutation may not necessarily develop disease symptoms. “Penetrance” refers to the proportion of individuals carrying the disease-causing mutation that Read More…
Written by Alexandra Putka Edited by Dr. Hayley S. McLoughlin Walking measurements detect changes in SCA3 severity across a 1-year study and represent an important biomarker of disease progression Medical doctors use a number of tools to assess a patient’s health: a thermometer and blood pressure monitor, for example. These Read More…
Augmentative and Alternative Communication (AAC) is an umbrella term that has many meanings. Simply put, AAC is every way we communicate other than speaking. At its core, AAC uses symbols. For a message to be considered AAC, it must be represented symbolically. AAC must stand for something else. A simple Read More…
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